Risk factors for progression of brain atrophy in aging: Six-year follow-up of normal subjects

C. Enzinger, F. Fazekas, P. M. Matthews, S. Ropele, H. Schmidt, S. Smith, R. Schmidt

Code and Data Abstract

We assessed the brain parenchymal fraction at baseline and subsequent annual brain volume changes over 6 years for 201 participants (F/M = 96/105; 59.8 ± 5.9 years) in the Austrian Stroke Prevention Study from 1.5-T MRI scans using SIENA (structural image evaluation using normalization of atrophy)/SIENAX (an adaptation of SIENA for cross-sectional measurement)(www.fmrib.ox.ac.uk/fsl). Hypertension, cardiac disease, diabetes mellitus, smoking, and regular alcohol intake were present in 64 (31.8%), 60 (29.9%), 5 (2.5%), 70 (39.3%), and 40 (20.7%) subjects, respectively. Plasma levels of fasting glucose (93.7 ± 18.6 mg/dL), glycated hemoglobin A (HbA1c; 5.6 ± 0.7%), total cholesterol (228.3 ± 40.3 mg/dL), and triglycerides (127.0 ± 75.2 mg/dL) were determined. WMH was rated as absent (n = 56), punctate (n = 120), early confluent (n = 14), and confluent (n = 11).

Article

C. Enzinger, F. Fazekas, P. M. Matthews, S. Ropele, et al. 2005. "Risk factors for progression of brain atrophy in aging: Six-year follow-up of normal subjects." Neurology. 64 (10) 1704–1711.    doi:10.1212/01.WNL.0000161871.83614.BB. Retrieved 09/15/2019 from researchcompendia.org/compendia/2014.448/

Compendium Type: Journal or Magazine Articles
Primary Research Field: Computer and Information Sciences
Secondary Research Field: Mathematics
Content License: Public Domain Mark
Code License: MIT License

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created 02/21/2014

modified 02/21/2014

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